Balotelli made his debut for his hometown club after completing a four-match suspension that he was handed at Olympique de Marseille last season, while the visitors were without Cristiano Ronaldo as he recovers from injury.
City are two points behind leaders Liverpool, but have a game in hand
Chelsea goalkeeper Kepa Arrizabalaga remains the club's first choice but manager Maurizio Sarri is still uncertain if the Spaniard will be recalled to the starting team for Sunday's Premier League trip to Fulham.
Manchester City suffered their first home Premier League loss in eight months as a shock 3-2 defeat by Crystal Palace on Saturday left Pep Guardiola's champions trailing leaders Liverpool by four points.
Liverpool and champions Manchester City drew 0-0 at Anfield while Chelsea and Arsenal enjoyed comfortable away wins. City are top on goal difference from Liverpool and Chelsea with Arsenal two points behind.
Manchester United battled back from two goals down to beat Newcastle United 3-2 at Old Trafford on Saturday as a 90th-minute winner from Alexis Sanchez completed a spirited comeback to ease the pressure on manager Jose Mourinho.
Liverpool made it three wins out of three as Mohamed Salah scored twice in a convincing 3-1 victory over Arsenal on Saturday to take control at the top of the Premier League.
Images from the English Premier League matches played on Saturday.
Manchester City overcame a spirited Bournemouth side 3-1 on Saturday to maintain their unbeaten streak and extend their lead at the top of the English Premier League to five points.
Peru made a positive and lasting impression all-round, whether for their enterprising performances or their travelling army of joyous fans
Manchester United striker Romelu Lukaku defended Jose Mourinho's confrontational style of management, saying that the Portuguese deserves respect for not hiding his true feelings like several Premier League bosses.
Raheem Sterling scored a hat-trick as champions Manchester City made a convincing start to their title defence with a 5-0 win over West Ham United.
Peru's entertaining team and their colourful army of joyous fans will be sorely missed at the World Cup after the South Americans fell victim to their old failing in front of goal.
Inter will be his sixth club in a career which began when he made his debut for Anderlecht as a 16-year-old and has taken him to Chelsea, West Bromwich Albion and Everton.
European champions Portugal were let off the hook by Morocco's wasteful finishing and another Cristiano Ronaldo moment as they notched up a fortuitous victory in the World Cup on Wednesday. Yet, the reactions of the respective coaches suggested a different result.
Eric Choupo-Moting scored his third Ligue 1 goal of the season on Sunday but the Paris St Germain forward's incredible miss later in the game was the moment that will be remembered from his performance in Sunday's 2-2 draw against Racing Strasbourg.
Salah, 25, struck four goals in Liverpool's 5-0 thrashing of Watford that lifted them back into third place in the Premier League on Saturday.
Premier League leaders Manchester City won their derby with United 3-1, while Liverpool kept pace with a home win over Fulham.
Tottenham Hotspur overcame a worrying injury to talismanic striker Harry Kane to beat mid-table Bournemouth 4-1 with a Son Heung-min double and goals from Dele Alli and Serge Aurier to move up to third in the Premier League.
The Arsenal manager says money and 'starification' has become too important in football.
Manchester City thrashed Southampton 6-1 to remain top of the Premier League.
'I can't comment on speculation. I don't bet and I don't do the lottery - it's not my way'
Images from the EPL matches played on Saturday
Brighton and Hove Albion made sure of Premier League football next season with two games to spare after a Pascal Gross goal gave them a memorable 1-0 home win over Manchester United on Friday.
The victory puts the pressure back on title rivals Liverpool who are at Cardiff City on Sunday and trail by a point with each side having played 34 games.
Tottenham Hotspur's England duo Harry Kane and Dele Alli fired them to a comfortable 2-0 win over mid-table Watford that cemented their place in the top four at Wembley on Monday.
Real Madrid beat Leganes 2-1 in La Liga on Saturday after coach Zinedine Zidane heavily rotated his side in preparation for Tuesday's Champions League semi-final second leg against Bayern Munich, including leaving out top-scorer Cristiano Ronaldo.
News of all that's transpired on and off the football field
Manchester City emerged from a trough of despair to beat Tottenham Hotspur 3-1 and move to within three points of the Premier League title at Wembley on Saturday.
IMAGES from the English Premier League match played on Saturday
Top-class goals from Bernardo Silva and Sergio Aguero took Manchester City back to the top of the Premier League in a 2-0 win over Fulham at Craven Cottage on Saturday.
News of all that's transpired on and off the football field
Images from the English Premier League matches played on Saturday
News of all that's transpired on and off the football field.
Some highlights from this action-packed weekend we give to in this beautiful package...
Manager Mauricio Pochettino bemoaned his side's first half display as Tottenham Hotspur's poor run of form continued with a disappointing 2-1 defeat at Leicester City in the Premier League on Tuesday.
Mourinho takes a veiled jibe at Lukaku
News of all that's transpired on and off the football field
Mohamed Salah was inevitably on the scoresheet as Liverpool took full advantage of the inactivity of their top-four rivals to thrash West Ham United 4-1 at Anfield and provisionally move into second in the Premier League.
News of all that's transpired on and off the football field